منابع مشابه
Phosphorylation of RyR2 and shortening of RyR2 cluster spacing in spontaneously hypertensive rat with heart failure.
As a critical step toward understanding the role of abnormal intracellular Ca(2+) release via the ryanodine receptor (RyR(2)) during the development of hypertension-induced cardiac hypertrophy and heart failure, this study examines two questions: 1) At what stage, if ever, in the development of hypertrophy and heart failure is RyR(2) hyperphosphorylated at Ser(2808)? 2) Does the spatial distrib...
متن کامل“Stabilizing” the stabilizing controllers
The main purpose of this paper is to revisit the internal/simultaneous/robust stabilization problems without assuming the existence of doubly coprime factorizations for the transfer matrices. Indeed, it has been recently shown in the literature that an internally stabilizable does not generally admit doubly coprime factorizations. Firstly, we give new necessary and sufficient conditions for int...
متن کاملLeaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy.
Patients with Duchenne muscular dystrophy (DMD) have a progressive dilated cardiomyopathy associated with fatal cardiac arrhythmias. Electrical and functional abnormalities have been attributed to cardiac fibrosis; however, electrical abnormalities may occur in the absence of overt cardiac histopathology. Here we show that structural and functional remodeling of the cardiac sarcoplasmic reticul...
متن کاملR4496C RyR2 mutation impairs atrial and ventricular contractility
Ryanodine receptor (RyR2) is the major Ca(2+) channel of the cardiac sarcoplasmic reticulum (SR) and plays a crucial role in the generation of myocardial force. Changes in RyR2 gating properties and resulting increases in its open probability (Po) are associated with Ca(2+) leakage from the SR and arrhythmias; however, the effects of RyR2 dysfunction on myocardial contractility are unknown. Her...
متن کاملStabilizing bisets
Let G be a finite group and let R be a commutative ring. We analyse the (G,G)-bisets which stabilize an indecomposable RG-module. We prove that the minimal ones are unique up to equivalence. This result has the same flavor as the uniqueness of vertices and sources up to conjugation and resembles also the theory of cuspidal characters in the context of Harish-Chandra induction for reductive grou...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Science-Business eXchange
سال: 2012
ISSN: 1945-3477
DOI: 10.1038/scibx.2012.971